Publications

 

  1. A. San Millan and R.C MacLean. Fitness Costs of Plasmids: A Limit to Plasmid Transmission. Microbiology Spectrum (2017) doi:10.1128/microbiolspec.MTBP-0016-2017 [Link]
  2. A. San Millan, J.A Escudero*, D.Gifford*, D. Mazel and R.C MacLean. Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria. Nature Ecology and Evolution (2016) DOI:10.1038/s41559-016-0010 [Link] [Nature Microbiology Comment][Faculty of 1000][Behind the paper]
  3. T. Vogwill, R.L Phillips, D. Gifford and R.C MacLean.  Divergent evolution peaks under intermediate Population Bottlenecks during bacterial Experimental Evolution. Proceedings of the Royal Society of London B (2016) DOI: 10.1098/rspb.2016.0749 [Link]
  4. M.Toll-Riera, A. San Millan, A. Wagner and R. C MacLean. The genomic basis of evolutionary innovation in Pseudomonas aeruginosa. PLOS Genetics (2016) doi:10.1371/journal.pgen.1006005 [Link]
  5. A. Betts, D. Gifford, R.C MacLean and K. King. Parasite Diversity Drives Rapid Host Dynamics And Evolution Of Resistance In A Bacteria-Phage System. Evolution (2016) DOI: 10.1111/evo.12909 [Link]
  6. Vogwill, A. Comfort and R. C MacLean. Persistence and resistance as complementary bacterial adaptations to antibiotics. Journal of Evolutionary Biology (2016) DOI:10.1111/jeb.12864 [Link]
  7. D.Gifford, M. Toll-Riera and R. C MacLan. Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in rifampicin resistant Pseudomonas aeruginosa. Evolution (2016) DOI: 10.1111/evo.12958 [Link]
  8. T. Vogwill, M. Kojadinovic and R.C MacLean. Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of PseudomonasProceedings of the Royal Society of London B  (2016) DOI: 10.1098/rspb.2016.0151 [Link]
  9. D. Gifford, E. Moss and R.C MacLean. Environmental variation alters the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosaEvolution (2016) DOI: 10.1111/evo.12880 [Link]
  10. Q. Qi, M. Toll-Riera, K. Heilbron , G.M Preston and R.C MacLean. The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa. Proceedings of the Royal Society of London B (2016) DOI: 10.1098/rspb.2015.2452 [Link][Der Standard]
  11.  [Link]
  12. R.Craig MacLean and A. San Millan. Microbial Evolution: Towards Resolving the Plasmid Paradox (Dispatch). Current Biology  (2015) 25 R764–R767 doi:10.1016/j.cub.2015.07.006 [Link]
  13. A. San Millan, M. Toll-Riera, J. Escudero, R. Canton, T.Coque and R.C MacLean. Sequencing of plasmids PAMBL-1 and PAMBL-2 from Pseudomonas aeruginosa reveals a blaVIM-1 amplification causing high-level carbapenem resistance. Journal of Antimicrobial Chemotherapy (2015) doi: 10.1093/jac/dkv222 [Link]
  14. R. Peña-Miller, R. Rodríguez-González, R. C. MacLean and A. San Millan. Evaluating the effect of horizontal transmission on the stability of plasmids under different selection regimes. Mobile Genetic Elements (2015) 5(3) 1-5 doi:10.1080/2159256X.2015.1045115 [Link]
  15. D.Gifford, Macarena Toll-Riera, Mila Kojadinovic and R.C. MacLean. Here’s to the losers: evolvable residents accelerate the evolution of high fitness invaders. American Naturalist (2015) 186(1) 41-9 doi: 10.1086/681598 [Link]
  16. A. San Millan, M. Toll-Riera, Q. Qi and R.C. MacLean. Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa. Nature Communications (2015) 6, doi:10.1038/ncomms7845 [Link]
  17. R.C MacLean and T. Vogwill. Limits to compensatory adaptation and the persistence of antibiotic resistance in pathogenic bacteria. Evolution, Medicine and Public Health (2015) doi:10.1093/emph/eou032 [Link]
  18. Q, Qi, G. Preston and R.C. MacLean. Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa. mBio (2014) 5, doi: 10.1128/mBio.01562-14 [Link]
  19. A. San Millan*, R.Peña-Miller*, M. Toll-Riera, Z.Halbert, A.McLean, B.Cooper and R.C MacLean. Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids. Nature Communications (2014) 5, doi:10.1038/ncomms6208. [Link]
  20. T. Vogwill, M. Kojadinovic, V. Furió and R.C. MacLean. Testing the role of genetic background in parallel evolution using the comparative experimental evolution of antibiotic resistance. Molecular Biology and Evolution (2014) doi: 10.1093/molbev/msu262 [Link]
  21. T. Vogwill and R. C. MacLean. The genetic basis of the fitness cost of antimicrobial resistance: a meta-analysis approach. Evolutionary Applications (2014) doi:10.1111/eva.12202 [Link]
  22. K.Heilbron, M. Toll-Riera, M. Kojadinovic and R.C MacLean. Fitness is strongly influenced by rare mutations of large effect in a microbial mutation accumulation experiment. Genetics (2014) 197:981-990. [Link]
  23. E.Harrison, V. Koufopannou, R.C. MacLean and A.Burt. Sex drives intragenomic conflict in yeast. Journal of Evolutionary Biology (2014) 27:1757-1763. [Link]
  24. A. San Millan, Karl Heilbron and R.C. MacLean. Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations. ISME Journal. doi: 10.1038/ismej.2013.182. [Link]
  25. D.R. Gifford and R.C. MacLean. Evolutionary reversals of antibiotic resistance in experimental populations of Pseudomonas aeruginosa. Evolution (2013) 67:2973-2981. [Link]
  26. R.C. MacLean, C. Torres-Barceló and R. Moxon. Evaluating models of stress-induced mutagenesis in bacteria. Nature Reviews Genetics (2013) 14:221-227. [Link] [Faculty of 1000]
  27. C. Torres-Barceló, G.Cabot, A.Oliver, A. Buckling and R.C. MacLean. A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria. Proceedings of the Royal Society of London B Series B (2013) 280:1757 20130007. [Link]
  28. E. Harrison, V. Koufopannou, A. Burt and R.C. MacLean. The cost of copy number in a selfish genetic element: the 2-µm plasmid of Saccharomyces cerevisiae. Journal of Evolutionary Biology (2012) 11:2348-2356. [Link]
  29. A. Hall and R.C. MacLean. Epistasis buffers the fitness effects of rifampicin resistance mutations. Evolution (2011) 65:2370-2379. [Link]
  30. A.Hall, J. Iles, and R.C. MacLean. The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase. Genetics (2011) 187: 817-822 [Link]
  31. R.C. MacLean, G.G. Perron, and A. Gardner. Diminishing Returns from Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa. Genetics (2010) 186:1-10. [Link]
  32. R.C. MacLean*, A. Fuentes-Hernandez* , D. Greig , L.D Hurst LD, and I. Gudelj. A Mixture of “Cheats” and “Co-Operators” Can Enable Maximal Group Benefit. PLoS Biology (2010) 8: e1000486. [Link]
  33. R.C. MacLean, A. Hall, G. Perron, and A. Buckling. The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment context. Nature Reviews Genetics (2010) 11:405-414. [Link]
  34. R.C. MacLean. Predicting epistasis: an experimental test of metabolic control theory with bacterial transcription and translation. Journal of Evolutionary Biology (2010) 23(3)488-493. [Link]
  35. A.Hall, V. Griffiths, R.C MacLean* and N.Colegrave*. Mutational Neighbourhood and Mutation Supply Rate Constrain Adaptation in Pseudomonas aeruginosa. Proceedings of the Royal Society of London Series B (2010) 277(1681) 643-650 [Link]
  36. H. Ward, G.G. Perron, and R.C. MacLean .The cost of multiple drug resistance in Pseudomonas aeruginosa. Journal of Evolutionary Biology (2009) 22(5)997-1003. [Link]
  37. R. C. MacLean and A. Buckling. The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa. PLoS Genetics (2009) 5(3): e1000406. [Link]
  38. A. Buckling, R.C. MacLean, M. Brockhurst, and N. Colegrave. The Beagle in a bottle. Nature (2009) 457:824-829. [Link]
  39. R.C. MacLean and C. Brandon. Stable public goods cooperation and dynamic social interactions in yeast. Journal of Evolutionary Biology (2008) 21(6): 1836-1843. [Link]
  40. P.A. Venail*, R.C. MacLean*, T. Bouvier, M. Brockhurst, M.E. Hochberg, and N. Mouquet. Diversity and productivity peak at intermediate dispersal rate in evolving metacommunities. Nature (2008) 452:210-214. [Link] [Faculty of 1000]
  41. R.C. MacLean. The tragedy of the commons in microbial populations: insights from theoretical, comparative and experimental studies. Heredity (2008) 100:233-239.[Link]
  42. I. Gudelj, R.E. Beardmore, S. Arkin, and R.C. MacLean. Constraints on microbial metabolism drive evolutionary diversification in homogeneous environments. Journal of Evolutionary Biology (2007) 20(5):1882-1889.[Link] [Faculty of 1000]
  43. R.C. MacLean. Pleiotropy and GAL pathway degeneration in yeast. Journal of Evolutionary Biology (2007) 20 (4): 1333–1338. [Link]
  44. R.C. MacLean and I. Gudelj. Resource competition and social conflict in experimental populations of yeast. Nature (2006) 441:498-501. [Link] [Faculty of 1000]
  45. R.D.H. Barrett, R.C. MacLean, and G. Bell. Mutations of intermediate effect are responsible for adaptation in evolving populations of Pseudomonas fluorescens. Biology Letters (2006) 2:236-238. [Link]
  46. R.D.H Barrett, R.C. MacLean, and G. Bell. Experimental evolution of Pseudomonas fluorescens in simple and complex environments. American Naturalist (2005) 166:470-480. [Link] [Faculty of 1000]
  47. R.C. MacLean. Adaptive radiation in microbial microcosms. Journal of Evolutionary Biology (2005)18:1376-86. [Link]
  48. R.C. MacLean, A. Dickson, and G. Bell. Resource competition and adaptive radiation in a microbial microcosm. Ecology Letters (2005) 8:36-46. [Link] [Faculty of 1000]
  49. R.C. MacLean, P.B Rainey, and G. Bell. The evolution of a pleiotropic fitness trade-off in Pseudomonas fluorescens. Proceedings of the National Academy of Sciences of the USA (2004) 101:8072-8077. [Link] [Faculty of 1000]
  50. R.C MacLean and G. Bell. Divergent evolution during an experimental adaptive radiation. Proceedings of the Royal Society of London Series B (2003) 270:1645-1650. [Link]
  51. D. Bélotte, J-B. Curien, R.C. MacLean, and G. Bell. An Experimental Test of Local Adaptation in Soil Bacteria. Evolution (2003) 57:27-36. [Link]
  52. R.C. MacLean and G. Bell. Experimental Adaptive Radiation in Pseudomonas. American Naturalist (2002) 160:569-581. [Link]
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